How To Take BioTrim RX Caplets. Take two tablets by mouth daily with or without food. If you have any issues when taking it one way or the other. Just switch until you find what works best for you as far as taking it with or without food goes. For the best results its recommended that you keep this supplement in a cool and dry place also out the reach of children. If you are under a physician’s care or taking medications. It would be in your best benefit to consult with them first and see if this will interfere with your current routine. If you’re pregnant or nursing you do the same just to be on the safe side.